TY - BOOK AU - McClellan, Roger O. TI - Toxicology : : Tobacco-Specific N-Nitrosamines : Recent Advances / SN - 9780849311567 U1 - 615.9 PY - 1996/// CY - New York : PB - CRC Press, KW - Conference papers and proceedings KW - Tobacco Toxicology Congresses KW - Nitrosoamines Toxicology Congresses N1 - Cover title "Special issue"--Page [1] "This book is a reproduction of Critical reviews in toxicology, volume 26, Issue 2"--Page [1] Six papers presented at a symposium on tobacco-specific n-nitrosamines at the 16th International Cancer Congress, Oct.-Nov. 1994, New Delhi; Includes bibliographical references and indexes; 1. Introduction; 2. Formation and Analysis of Tobacco-Specific N-Nitrosamines; 3. Synthesis of Tobacco-Specific N-Nitrosamines and Their Metabolites and Results of Related Bioassays; 4. Endogenous Formation of Nitrosamines and Oxidative DNA-Damaging Agents in Tobacco Users; 5. Recent Studies on Mechanisms of Bioactivation and Detoxification of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK), A Tobacco-Specific Lung Carcinogen; 6. Epidemiology of Cancer by Tobacco Products and the Significance of TSNA; 7. The Biological Significance of Tobacco-Specific N-Nitrosamines: Smoking and Adenocarcinoma of the Lung; 8. Comparative Carcinogenicity, Metabolism, Mutagenicity, and DNA Binding of 7H-Dibenzo[c,g]carhazole and Dibenz[a,j]acridine; 9. Concluding Remarks N2 - This book presents critical assessments of subjects that are part of the advancing frontiers of toxicology and related basic scientific disciplines or issues that form the core of some of the most complex and intractable problems with which the toxicologist has to grapple ER -