Tobacco-Specific N-Nitrosamines : Recent Advances McClellan, Roger O. creator Editor text biography us New York CRC Press 1996 1st ed. monographic eng

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119-253 pages : illustrations ; 29 cm This book presents critical assessments of subjects that are part of the advancing frontiers of toxicology and related basic scientific disciplines or issues that form the core of some of the most complex and intractable problems with which the toxicologist has to grapple. 1. Introduction 2. Formation and Analysis of Tobacco-Specific N-Nitrosamines 3. Synthesis of Tobacco-Specific N-Nitrosamines and Their Metabolites and Results of Related Bioassays 4. Endogenous Formation of Nitrosamines and Oxidative DNA-Damaging Agents in Tobacco Users 5. Recent Studies on Mechanisms of Bioactivation and Detoxification of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK), A Tobacco-Specific Lung Carcinogen 6. Epidemiology of Cancer by Tobacco Products and the Significance of TSNA 7. The Biological Significance of Tobacco-Specific N-Nitrosamines: Smoking and Adenocarcinoma of the Lung 8. Comparative Carcinogenicity, Metabolism, Mutagenicity, and DNA Binding of 7H-Dibenzo[c,g]carhazole and Dibenz[a,j]acridine 9. Concluding Remarks Roger O. McClellan Cover title "Special issue"--Page [1] "This book is a reproduction of Critical reviews in toxicology, volume 26, Issue 2"--Page [1] Six papers presented at a symposium on tobacco-specific n-nitrosamines at the 16th International Cancer Congress, Oct.-Nov. 1994, New Delhi. Includes bibliographical references and indexes. Conference papers and proceedings Tobacco Toxicology Congresses Nitrosoamines Toxicology Congresses 615.9 MCT 9780849311567 084931156X 241117 20241117113116.0 18368